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TitleEngineered IL-18 variants with half-life extension and improved stability for cancer immunotherapy.
Journal, issue, pagesJ Immunother Cancer, Vol. 13, Year 2025
Publish dateApr 25, 2025 (structure data deposition date)
AuthorsBainbridge, T.W. / Wang, L. / Moskalenko, M. / Herrera, R. / Paluch, M.T. / Sun, D. / Tasneem, K. / Saini, H. / Sadek, M. / Kwong, M. ...Bainbridge, T.W. / Wang, L. / Moskalenko, M. / Herrera, R. / Paluch, M.T. / Sun, D. / Tasneem, K. / Saini, H. / Sadek, M. / Kwong, M. / Kim, Y.M. / Bhatt, J.M. / Tam, C. / Chan, P.P.F. / Ovacik, A.M. / Masureel, M. / Zhao, Y. / Sockolosky, J.T. / Qu, Y. / West, N.R. / Bulutoglu, B.
External linksJ Immunother Cancer / PubMed:40664452
MethodsX-ray diffraction
Resolution1.6 - 1.9 Å
Structure data

PDB-9od7:
Structure of disulfide-stabilized IL-18 variant
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-9od9:
Structure of disulfide-stabilized IL-18 variant
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCYTOKINE / protein structure

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