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TitleDifferential control of RNA demethylase activity and selectivity by cofactor ascorbate.
Journal, issue, pagesBiorxiv, Year 2025
Publish dateMay 5, 2025 (structure data deposition date)
AuthorsCalzini, L.O. / Warminski, M. / Kowalska, J. / Jemielity, J. / Mugridge, J.S.
External linksBiorxiv / PubMed:40654844
MethodsX-ray diffraction
Resolution3.072 Å
Structure data

PDB-9ohs:
Crystal structure of human FTO in complex with Ga(III) and ascorbate
Method: X-RAY DIFFRACTION / Resolution: 3.072 Å

Chemicals

ChemComp-GA:
GALLIUM (III) ION

ChemComp-ASC:
ASCORBIC ACID / medication*YM

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Fe(II)/2-oxoglutarate-dependent dioxygenase / RNA demethylase / RNA modifying enzyme / AlkB homolog

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