Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Rational optimization of D3R/GSK-3 beta dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies.
Journal, issue, pages	Eur. J. Med. Chem., Vol. 297, Page 117899-117899, Year 2025
Publish date	Dec 23, 2024 (structure data deposition date)
Authors	Di Martino, R.M.C. / Russo, D. / Penna, I. / Demuro, S. / Dalle Vedove, A. / Spagnuolo, R. / Ottonello, G. / Bertozzi, S.M. / Summa, M. / Desantis, J. ...Di Martino, R.M.C. / Russo, D. / Penna, I. / Demuro, S. / Dalle Vedove, A. / Spagnuolo, R. / Ottonello, G. / Bertozzi, S.M. / Summa, M. / Desantis, J. / Valeri, A. / Pruccoli, L. / Tripathi, S.K. / Tarozzi, A. / Storici, P. / Girotto, S. / Bertorelli, R. / Armirotti, A. / Cruciani, G. / Bandiera, T. / Cavalli, A. / Bottegoni, G.
External links	Eur. J. Med. Chem. / PubMed:40639291
Methods	X-ray diffraction
Resolution	2.9 - 3.5 Å
Structure data	PDB-9huk: Crystal structure of human GSK3b in complex with ARN24161 Method: X-RAY DIFFRACTION / Resolution: 3.5 Å PDB-9hul: Crystal structure of human GSK3b in complex with ARN25423 Method: X-RAY DIFFRACTION / Resolution: 2.9 Å PDB-9hv3: Crystal structure of human GSK3b in complex with ARN25657 Method: X-RAY DIFFRACTION / Resolution: 2.9 Å
Chemicals	PDB-1ixl: Crystal structure of uncharacterized protein PH1136 from Pyrococcus horikoshii PDB-1ixm: CRYSTAL STRUCTURE OF SPOOB FROM BACILLUS SUBTILIS PDB-1ixn: Enzyme-Substrate Complex of Pyridoxine 5'-Phosphate Synthase
Source	homo sapiens (human)
Keywords	TRANSFERASE / kinase inhibitors / multitarget compounds / drug discovery / bipolar disorder