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TitleStructure of ClfA002 in Complex With Neutralizing Antibody AZD7745 Provides Insight into Its Broad Neutralization Mechanism in Staphylococcus aureus Infection.
Journal, issue, pagesJ. Infect. Dis., Vol. 232, Page e421-e430, Year 2025
Publish dateFeb 28, 2025 (structure data deposition date)
AuthorsTkaczyk, C. / Keren-Kaplan, T. / Gamson, A. / Warrener, P. / Semenova, E. / Rosenthal, K. / Barnes, A. / Ahani, B. / Sellman, B.R. / Podlaha, O. / Oganesyan, V.
External linksJ. Infect. Dis. / PubMed:40632825
MethodsX-ray diffraction
Resolution1.58 Å
Structure data

PDB-9njy:
Terminal two domains of ClfA002 with bound Fab of AZD7745
Method: X-RAY DIFFRACTION / Resolution: 1.58 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • staphylococcus aureus (bacteria)
  • mammalia (mammals)
KeywordsIMMUNE SYSTEM / Staphylococcus Aureus / virulence factors / monoclonal antibody / prophylactic treatment

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