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TitleInternal Ubiquitin Electrophiles for Covalent Trapping and Inhibition of Deubiquitinases.
Journal, issue, pagesChembiochem, Vol. 26, Page e202500318-e202500318, Year 2025
Publish dateApr 8, 2025 (structure data deposition date)
AuthorsPannala, N.M. / Patel, R.S. / Anit, A.S. / Bhattacharya, D. / Teron, K.N. / Drown, B. / Fasan, R. / Das, C.
External linksChembiochem / PubMed:40626928
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-9o4m:
Crystal structure of Ubiquitin Carboxy Terminal Hydrolase L1 Q209C mutant covalently crosslinked to ubiquitin genetically encoded with N6-(6-bromohexanoyl)-L-lysine
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-6NA:
HEXANOIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / UCHL1 / genetic code expansion / covalent trapping / unnatural amino acid / ubiquitin

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