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Structure paper

TitleStructural and functional analyses of SARS-CoV-2 Nsp3 and its specific interactions with the 5' UTR of the viral genome.
Journal, issue, pagesMicrobiol Spectr, Vol. 13, Page e0287124-e0287124, Year 2025
Publish dateSep 30, 2020 (structure data deposition date)
AuthorsLemak, S. / Skarina, T. / Patel, D.T. / Stogios, P.J. / Savchenko, A.
External linksMicrobiol Spectr / PubMed:40621910
MethodsX-ray diffraction
Resolution2.17 - 3.21 Å
Structure data

PDB-7kag:
Crystal structure of the ubiquitin-like domain 1 (Ubl1) of Nsp3 from SARS-CoV-2
Method: X-RAY DIFFRACTION / Resolution: 3.21 Å

PDB-7lgo:
Crystal structure of the nucleic acid binding domain (NAB) of Nsp3 from SARS-CoV-2
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

PDB-7rqg:
Crystal structure of the Nsp3 Y3 domain from SARS-CoV-2
Method: X-RAY DIFFRACTION / Resolution: 2.17 Å

PDB-7t9w:
Crystal structure of the Nsp3 bSM (Betacoronavirus-Specific Marker) domain from SARS-CoV-2
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-7ti9:
Crystal structure of the ubiquitin-like domain 1 (Ubl1) of Nsp3 from SARS-CoV-2, form 2
Method: X-RAY DIFFRACTION / Resolution: 2.73 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-GOL:
GLYCEROL

Source
  • severe acute respiratory syndrome coronavirus 2
KeywordsVIRAL PROTEIN / SARS-COV-2 / NON-STRUCTURAL PROTEIN / NSP3 / UBIQUITIN-LIKE DOMAIN / STRUCTURAL GENOMICS / CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES / CSGID / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES / NIAID / RNA BINDING PROTEIN / NUCLEIC ACID BINDING DOMAIN / CENTER FOR STRUCTURAL GENOMICS INFECTIOUS DISEASES / COVID-19 / non-structural protein 3 / Y3 domain / unknown function / BSM domain / Betacoronavirus-Specific Marker / G2M / group 2 marker

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