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TitleS N Ar Reactive Pyrazine Derivatives as p53-Y220C Cleft Binders with Diverse Binding Modes.
Journal, issue, pagesDrug Des Devel Ther, Vol. 19, Page 4727-4753, Year 2025
Publish dateJul 17, 2024 (structure data deposition date)
AuthorsKlett, T. / Stahlecker, J. / Schwer, M. / Jaag, S.J. / Masberg, B. / Knappe, C. / Lammerhofer, M. / Stehle, T. / Boeckler, F.M.
External linksDrug Des Devel Ther / PubMed:40599607
MethodsX-ray diffraction
Resolution1.56 - 1.65 Å
Structure data

PDB-9g5h:
p53-Y220C Core Domain Covalently Bound to 2-chloro-5-cyanopyrazine Soaked at 5 mM
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-9g6t:
p53-Y220C Core Domain Covalently Bound to 5-Chloro-6-methylpyrazine-2-carbonitrile Soaked at 5 mM
Method: X-RAY DIFFRACTION / Resolution: 1.56 Å

PDB-9g6u:
p53-Y220C Core Domain Covalently Bound to 3,5-Dichloro-6-Ethylpyrazine-2-carbonitirle Soaked at 5 mM
Method: X-RAY DIFFRACTION / Resolution: 1.64 Å

Chemicals

PDB-1iio:
NMR-Based Structure of the Conserved Protein MTH865 from the Archea Methanobacterium thermoautotrophicum

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ZN:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

PDB-1ii4:
CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2

PDB-1ii1:
Structural Basis for Poor Uracil Excision from Hairpin DNA: NMR Study

ChemComp-PGE:
TRIETHYLENE GLYCOL

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / Covalent / SNAr / Stabilization

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