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Structure paper

TitleConformational dynamics and membrane insertion mechanism of B4GALNT1 in ganglioside synthesis.
Journal, issue, pagesNat Commun, Vol. 16, Page 5442-5442, Year 2025
Publish dateOct 24, 2024 (structure data deposition date)
AuthorsWelland, J.W.J. / Barrow, H.G. / Stansfeld, P.J. / Deane, J.E.
External linksNat Commun / PubMed:40593514
MethodsX-ray diffraction
Resolution2.674 - 2.96 Å
Structure data

PDB-9h6j:
Human B4GALNT1 Apo Structure
Method: X-RAY DIFFRACTION / Resolution: 2.96 Å

PDB-9h6k:
Human B4GALNT1 in Complex with UDP-GalNac
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-9h6l:
Human B4GALNT1 in Complex with UDP
Method: X-RAY DIFFRACTION / Resolution: 2.674 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-ACY:
ACETIC ACID

ChemComp-HOH:
WATER

ChemComp-UD2:
URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE

ChemComp-UDP:
URIDINE-5'-DIPHOSPHATE / UDP*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Glycosyltransferase / CAZy GT12 / Ganglioside Synthase / Glycosphingolipid Synthase / UDP-GalNac Complex / UDP Complex

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