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TitleCrystal structures of Mycobacterium tuberculosis and Mycobacterium thermoresistibile glycyl-tRNA synthetases in various liganded states.
Journal, issue, pagesPlos One, Vol. 20, Page e0326500-e0326500, Year 2025
Publish dateApr 21, 2023 (structure data deposition date)
AuthorsFenwick, M.K. / DeRocher, A.E. / Craig, J.K. / Harmon, E.K. / Seibold, S. / Liu, L. / Battaile, K.P. / Barrett, L.K. / Van Voorhis, W.C. / Phan, I.Q. ...Fenwick, M.K. / DeRocher, A.E. / Craig, J.K. / Harmon, E.K. / Seibold, S. / Liu, L. / Battaile, K.P. / Barrett, L.K. / Van Voorhis, W.C. / Phan, I.Q. / Staker, B.L. / Subramanian, S. / Lovell, S. / Myler, P.J.
External linksPlos One / PubMed:40587479
MethodsX-ray diffraction
Resolution1.65 - 2.9 Å
Structure data

PDB-8sld:
Crystal Structure of Glycine tRNA ligase from Mycobacterium thermoresistibile (Apo)
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

PDB-8slf:
Crystal Structure of Glycine tRNA ligase from Mycobacterium thermoresistibile (AMP bound)
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-8slg:
Crystal Structure of Glycine tRNA ligase from Mycobacterium thermoresistibile (glycyl adenylate bound)
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-8t5n:
Crystal Structure of Glycine--tRNA ligase from Mycobacterium tuberculosis (AMP-Mg bound)
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-8u2p:
Crystal Structure of Glycine--tRNA ligase from Mycobacterium tuberculosis (G5A bound)
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-ZN:
Unknown entry

ChemComp-G5A:
5'-O-(glycylsulfamoyl)adenosine

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-CA:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-IMD:
IMIDAZOLE

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-CL:
Unknown entry

Source
  • mycolicibacterium thermoresistibile atcc 19527 (bacteria)
  • mycobacterium tuberculosis (bacteria)
KeywordsLIGASE / SSGCID / STRUCTURAL GENOMICS / SEATTLE STRUCTURAL GENOMICS CENTER FOR INFECTIOUS DISEASE / Glycine--tRNA ligase / TRANSFERASE

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