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TitleDevelopment of Orally Bioavailable FTO Inhibitors with Potent Antileukemia Efficacy.
Journal, issue, pagesJ. Med. Chem., Vol. 68, Page 13714-13727, Year 2025
Publish dateNov 18, 2024 (structure data deposition date)
AuthorsYang, T. / Dong, Z. / Du, R. / Wang, Y. / Liu, L. / Xue, Y. / Zhang, X. / Liao, Y. / Gan, J. / Yu, X. ...Yang, T. / Dong, Z. / Du, R. / Wang, Y. / Liu, L. / Xue, Y. / Zhang, X. / Liao, Y. / Gan, J. / Yu, X. / Huang, Y. / Yang, C.G.
External linksJ. Med. Chem. / PubMed:40579742
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-9knh:
Structural complex of FTO bound with Dac590
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

PDB-1ef4:
SOLUTION STRUCTURE OF THE ESSENTIAL RNA POLYMERASE SUBUNIT RPB10 FROM METHANOBACTERIUM THERMOAUTOTROPHICUM

ChemComp-OGA:
N-OXALYLGLYCINE / inhibitor*YM

ChemComp-FE:
Unknown entry

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / N6-methyladenosine(m6A) demethylase / Inhibitor / Complex

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