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TitleDiscovery and Optimization of Selective Inhibitors of Large Tumor Suppressor Kinases LATS1 and 2 for In Vivo Investigation of the Hippo-YAP Pathway in Tissue Regeneration.
Journal, issue, pagesJ. Med. Chem., Year 2025
Publish dateNov 18, 2024 (structure data deposition date)
AuthorsNamoto, K. / Vangrevelinghe, E. / Machauer, R. / Behnke, D. / Buschmann, N. / Lachal, J. / Schipp, K. / Sorge, M. / Barker, K. / Fabbiani, F. ...Namoto, K. / Vangrevelinghe, E. / Machauer, R. / Behnke, D. / Buschmann, N. / Lachal, J. / Schipp, K. / Sorge, M. / Barker, K. / Fabbiani, F. / Piechon, P. / Connor, L.E. / Laurent, S. / Lohmann, F. / Unterreiner, V. / George, E.L. / Redmond, E. / Wang, L. / Scheufler, C. / Sohal, B. / Sailer, A.W. / Glatthar, R. / Tchorz, J.S. / Maibaum, J.
External linksJ. Med. Chem. / PubMed:40574495
MethodsX-ray diffraction
Resolution2.92 Å
Structure data

PDB-9hfp:
ROCK2 IN COMPLEX WITH CPD7
Method: X-RAY DIFFRACTION / Resolution: 2.92 Å

Chemicals

PDB-1iui:
Unknown entry

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / KINASE / complex structure / inhibitor

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