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TitleMonoclonal humanized monovalent antibody blocking therapy for anti-NMDA receptor encephalitis.
Journal, issue, pagesNat Commun, Vol. 16, Page 5292-5292, Year 2025
Publish dateMay 10, 2024 (structure data deposition date)
AuthorsKanno, A. / Kito, T. / Maeda, M. / Yamaki, S. / Amano, Y. / Shimomura, T. / Anisimova, M. / Kanazawa, N. / Suzuki, K. / Razai, A. ...Kanno, A. / Kito, T. / Maeda, M. / Yamaki, S. / Amano, Y. / Shimomura, T. / Anisimova, M. / Kanazawa, N. / Suzuki, K. / Razai, A. / Mihara, T. / Kubo, K. / Shimada, T. / Nakamura, K. / Nomura, N. / Kondo, Y. / Okimoto, A. / Sugiyama, A. / Park, D. / Stein, I. / Petshow, S. / Vandendoren, V. / Bilic, S. / Kazimi, R. / Eastman, V. / Snipas, S.J. / Mitchell, M. / Maurer, M. / Jefson, M. / Lichter, J. / Yamajuku, D. / Shirai, H. / Adachi, M. / Hoeppner, D.J. / Kubo, S. / Zito, K. / Iizuka, T. / Flynn, P. / Matsumoto, M.
External linksNat Commun / PubMed:40527893
MethodsX-ray diffraction
Resolution3.5 Å
Structure data

PDB-8zh7:
Crystal structure of N-terminal domain of N-methyl-D-aspartate receptor subunit NR1 in complex with patient-derived antibody
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Receptor / Transmembrane / Ion channel / Complex

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