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TitleStructural polymorphism of the antigenic loop in HBV surface antigen dictates binding of diverse neutralizing antibodies.
Journal, issue, pagesCell Discov, Vol. 11, Issue 1, Page 57, Year 2025
Publish dateJun 17, 2025
AuthorsXiao He / Weiyu Tao / Yunlu Kang / Jiaxuan Xu / Xiaoyu Liu / Lei Chen /
PubMed AbstractThe Hepatitis B Virus (HBV) poses a significant health threat, causing millions of deaths each year. Hepatitis B surface antigen (HBsAg), the sole membrane protein on the HBV viral envelope, plays ...The Hepatitis B Virus (HBV) poses a significant health threat, causing millions of deaths each year. Hepatitis B surface antigen (HBsAg), the sole membrane protein on the HBV viral envelope, plays crucial roles in viral attachment to host cells and serves as the target for neutralizing antibodies (NAbs). Despite its functional and therapeutic significance, the mechanisms by which NAbs recognize HBsAg remain elusive. Here, we found that HBsAg proteins exist in distinct subtypes and are recognized by different groups of antibodies. Cryo-electron microscopy (Cryo-EM) structures of HBsAg dimers in complex with NAb Fab fragments reveal that the antigenic loop (AGL) of these distinct HBsAg types share a common structural core comprised of four β-strands. However, their surface structures exhibit unexpected polymorphism due to distinct disulfide bond linkages within the AGL region. This structural polymorphism determines the recognition of HBsAg by different groups of NAbs.
External linksCell Discov / PubMed:40523894 / PubMed Central
MethodsEM (single particle)
Resolution3.09 - 3.25 Å
Structure data

61004

9iyy

EMDB-61004, PDB-9iyy:
Structure of HBsAg in complex with Fab H006
Method: EM (single particle) / Resolution: 3.13 Å

61788

9jt1

EMDB-61788, PDB-9jt1:
Structure of HBsAg in complex with FabHBC and FabGC1102
Method: EM (single particle) / Resolution: 3.09 Å

63960

9u9b

EMDB-63960, PDB-9u9b:
HBsAg in complex with HBC34 Fab
Method: EM (single particle) / Resolution: 3.25 Å

EMDB-64465: HBsAg AGL region in complex with HBC34 Fab variable region
Method: EM (single particle) / Resolution: 3.2 Å

EMDB-64466: HBsAg in complex with HBC34 Fab
Method: EM (single particle) / Resolution: 3.25 Å

EMDB-64467: HBsAg in complex with HBC34 Fab
Method: EM (single particle) / Resolution: 3.25 Å

Source
  • hbv genotype d3 (virus)
  • homo sapiens (human)
  • hepatitis b virus
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / HBV / HBsAg / VIRAL PROTEIN / Antibody / Fab / VIRAL PROTEIN-IMMUNE SYSTEM complex / IMMUNE SYSTEM/VIRAL PROTEIN / IMMUNE SYSTEM-VIRAL PROTEIN complex / Antigenic loop

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