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TitlePreferential tumor targeting of HER2 by iPSC-derived CAR T cells engineered to overcome multiple barriers to solid tumor efficacy.
Journal, issue, pagesCell Stem Cell, Vol. 32, Page 1087-1101.e4, Year 2025
Publish dateJul 22, 2024 (structure data deposition date)
AuthorsHosking, M.P. / Shirinbak, S. / Omilusik, K. / Chandra, S. / Kaneko, M.K. / Gentile, A. / Yamamoto, S. / Shrestha, B. / Grant, J. / Boyett, M. ...Hosking, M.P. / Shirinbak, S. / Omilusik, K. / Chandra, S. / Kaneko, M.K. / Gentile, A. / Yamamoto, S. / Shrestha, B. / Grant, J. / Boyett, M. / Cardenas, D. / Keegan, H. / Ibitokou, S. / Pavon, C. / Mizoguchi, T. / Ihara, T. / Nakayama, D. / Abujarour, R. / Lee, T.T. / Clarke, R. / Goodridge, J. / Peralta, E. / Maeda, T. / Takagi, J. / Arimori, T. / Kato, Y. / Valamehr, B.
External linksCell Stem Cell / PubMed:40472844
MethodsX-ray diffraction
Resolution2.09 Å
Structure data

PDB-9iut:
Crystal structure of cancer-specific anti-HER2 antibody H2Mab-250 in complex with epitope peptide
Method: X-RAY DIFFRACTION / Resolution: 2.09 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Fv-clasp / antibody / cancer-specific / HER2

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