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| Title | Designed miniproteins potently inhibit and protect against MERS-CoV. |
|---|---|
| Journal, issue, pages | Cell Rep, Vol. 44, Page 115760-115760, Year 2025 |
| Publish date | Jun 11, 2024 (structure data deposition date) |
Authors | Ragotte, R.J. / Tortorici, M.A. / Catanzaro, N.J. / Addetia, A. / Coventry, B. / Froggatt, H.M. / Lee, J. / Stewart, C. / Brown, J.T. / Goreshnik, I. ...Ragotte, R.J. / Tortorici, M.A. / Catanzaro, N.J. / Addetia, A. / Coventry, B. / Froggatt, H.M. / Lee, J. / Stewart, C. / Brown, J.T. / Goreshnik, I. / Sims, J.N. / Milles, L.F. / Wicky, B.I.M. / Glogl, M. / Gerben, S. / Kang, A. / Bera, A.K. / Sharkey, W. / Schafer, A. / Harkema, J.R. / Baric, R.S. / Baker, D. / Veesler, D. |
External links | Cell Rep / PubMed:40450691 |
| Methods | X-ray diffraction |
| Resolution | 1.85 - 2.1 Å |
| Structure data | ![]() PDB-9c7z: ![]() PDB-9dgo: |
| Chemicals | ![]() ChemComp-PG4: ![]() ChemComp-HOH: ![]() ChemComp-NAG: |
| Source |
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Keywords | DE NOVO PROTEIN / trimer / hallucination / de novo / VIRAL PROTEIN / MERS-CoV / miniproteins / neutralization / fusion / cryo-EM / biolayer interferometry / MERS-CoV strains / Structural Genomics / Seattle Structural Genomics Center for Infectious Disease / SSGCID |
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