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Structure paper

TitleThe HP1 box of KAP1 organizes HP1 alpha for silencing of endogenous retroviral elements in embryonic stem cells.
Journal, issue, pagesNat Commun, Vol. 16, Page 5066-5066, Year 2025
Publish dateJun 25, 2024 (structure data deposition date)
AuthorsGaurav, N. / O'Hara, R. / Hyder, U. / Qin, W. / Her, C. / Romero, H. / Kumar, A. / Marcaida, M.J. / Singh, R.K. / Hovius, R. ...Gaurav, N. / O'Hara, R. / Hyder, U. / Qin, W. / Her, C. / Romero, H. / Kumar, A. / Marcaida, M.J. / Singh, R.K. / Hovius, R. / Selvam, K. / Liu, J. / Martire, S. / Yao, Y. / Challa, A. / Dal Peraro, M. / Fierz, B. / Kono, H. / Cardoso, M.C. / Debelouchina, G.T. / Leonhardt, H. / D'Orso, I. / Banaszynski, L.A. / Kutateladze, T.G.
External linksNat Commun / PubMed:40450002
MethodsX-ray diffraction
Resolution2.15 - 2.4 Å
Structure data

PDB-9cdw:
Crystal structure of HP1alpha chromoshadow domain in complex with KAP1 peptide
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-9cea:
Crystal structure of HP1alpha chromoshadow domain
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

Chemicals

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION/PEPTIDE / HP1 / CSD domain / KAP1 / TRANSCRIPTION / TRANSCRIPTION-PEPTIDE complex / HP1a

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