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TitleCocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 122, Page e2505197122-e2505197122, Year 2025
Publish dateMar 3, 2025 (structure data deposition date)
AuthorsZhang, S. / Megarioti, A.H. / Hendricks, J.M. / Zhou, J. / Sun, Q. / Jia, D. / Olzmann, J.A.
External linksProc. Natl. Acad. Sci. USA / PubMed:40440064
MethodsX-ray diffraction
Resolution2.01 Å
Structure data

PDB-9m3m:
Structure of FSP1 in complex with FSEN1
Method: X-RAY DIFFRACTION / Resolution: 2.01 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-6FA:
6-HYDROXY-FLAVIN-ADENINE DINUCLEOTIDE

PDB-1emu:
STRUCTURE OF THE AXIN RGS-HOMOLOGOUS DOMAIN IN COMPLEX WITH A SAMP REPEAT FROM APC

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / complex monomer inhibitor

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