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TitleACE2 from Pipistrellus abramus bats is a receptor for HKU5 coronaviruses.
Journal, issue, pagesNat Commun, Vol. 16, Issue 1, Page 4932, Year 2025
Publish dateMay 28, 2025
AuthorsNicholas J Catanzaro / Ziyan Wu / Chengcheng Fan / Victoria Jefferson / Anfal Abdelgadir / Alexandra Schäfer / Boyd L Yount / Pamela J Bjorkman / Ralph Baric / Michael Letko /
PubMed AbstractThe merbecovirus subgenus of coronaviruses includes Middle East Respiratory Syndrome Coronavirus (MERS-CoV), a zoonotic pathogen transmitted from dromedary camels to humans that causes severe ...The merbecovirus subgenus of coronaviruses includes Middle East Respiratory Syndrome Coronavirus (MERS-CoV), a zoonotic pathogen transmitted from dromedary camels to humans that causes severe respiratory disease. Viral discovery efforts uncover hundreds of merbecoviruses in different species across multiple continents, but few are studied under laboratory conditions, leaving basic questions regarding their human threat potential unresolved. Viral entry into host cells is a critical step for transmission between hosts. Here, we develop and apply a scalable approach to assesses novel merbecovirus cell entry across the entire merbecovirus subgenus. Merbecoviruses are sorted into clades based on the receptor-binding domain of the spike glycoprotein. Receptor tropism is clade-specific, with the clade including MERS-CoV using DPP4 and multiple clades using ACE2, including HKU5 bat coronaviruses. Mutational analysis identifies possible structural limitations to HKU5 adaptability and a cryo-EM structure of the HKU5-20s spike trimer reveals only 'down' RBDs.
External linksNat Commun / PubMed:40436893 / PubMed Central
MethodsEM (single particle)
Resolution2.8 Å
Structure data

46569

9d4t

EMDB-46569, PDB-9d4t:
Structure of HKU5-20s spike glycoprotein
Method: EM (single particle) / Resolution: 2.8 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • pipistrellus bat coronavirus hku5
KeywordsVIRAL PROTEIN / Merbecovirus / HKU5 / HKU5-20s / Spike

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