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Structure paper

TitleStructural and functional insights into the substrate specificity of the pseudouridine monophosphate phosphatase HDHD1A.
Journal, issue, pagesJ. Biol. Chem., Vol. 301, Page 110257-110257, Year 2025
Publish dateMar 10, 2025 (structure data deposition date)
AuthorsSeo, S. / Kim, M. / Rhee, S.
External linksJ. Biol. Chem. / PubMed:40409548
MethodsX-ray diffraction
Resolution1.26 - 1.36 Å
Structure data

PDB-9m7l:
Crystal structure of Pseudouridine 5'-monophosphate phosphatase from human (hHDHD1A) in the unliganded state
Method: X-RAY DIFFRACTION / Resolution: 1.36 Å

PDB-9m7m:
Crystal structure of human pseudouridine 5'-monophosphate phosphatase (hHDHD1A) complexed with pseudouridine
Method: X-RAY DIFFRACTION / Resolution: 1.26 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-FJF:
5-[(2~{S},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-1~{H}-pyrimidine-2,4-dione

Source
  • homo sapiens (human)
KeywordsRNA BINDING PROTEIN / pseudouridine monophosphate phosphatase / HAD phosphatase / cofactor / pseudouridine

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