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Structure paper

TitleMitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 122, Page e2418525122-e2418525122, Year 2025
Publish dateDec 1, 2024 (structure data deposition date)
AuthorsProta, G. / Berloffa, G. / Awad, W. / Vacchini, A. / Chancellor, A. / Schaefer, V. / Constantin, D. / Littler, D.R. / Colombo, R. / Nosi, V. ...Prota, G. / Berloffa, G. / Awad, W. / Vacchini, A. / Chancellor, A. / Schaefer, V. / Constantin, D. / Littler, D.R. / Colombo, R. / Nosi, V. / Mori, L. / Rossjohn, J. / De Libero, G.
External linksProc. Natl. Acad. Sci. USA / PubMed:40354545
MethodsX-ray diffraction
Resolution2.15 - 2.22 Å
Structure data

PDB-9ek6:
Crystal structure of MAIT TCR in complex with MR1-5FU
Method: X-RAY DIFFRACTION / Resolution: 2.22 Å

PDB-9ek7:
Crystal structure of MAIT TCR in complex with MR1-5FdU
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

Chemicals

ChemComp-TDR:
THYMINE

ChemComp-GOL:
GLYCEROL

ChemComp-ACT:
ACETATE ION

ChemComp-NA:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER


ChemComp, No image

ChemComp-YC6:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-THM:
THYMIDINE

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / receptor

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