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TitleOvercoming CK1 alpha liability in the discovery of a series of isoIndolinone Glutarimides as selective IKZF2 molecular glue degraders.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 124, Page 130263-130263, Year 2025
Publish dateApr 17, 2025 (structure data deposition date)
AuthorsZhang, X. / Deng, Q. / Dhruv, H. / Tudor, M. / Nagilla, R. / Jolivette, L.J. / Rice, C.T. / Orth, P. / Behshad, E. / Strickland, C.O. ...Zhang, X. / Deng, Q. / Dhruv, H. / Tudor, M. / Nagilla, R. / Jolivette, L.J. / Rice, C.T. / Orth, P. / Behshad, E. / Strickland, C.O. / Mohammad, H.P. / Sui, Z. / Priestley, E.S.
External linksBioorg. Med. Chem. Lett. / PubMed:40334997
MethodsX-ray diffraction
Resolution1.86 Å
Structure data

PDB-9o91:
Structure of IKZF2:CRBN:Compound 5 ternary structure
Method: X-RAY DIFFRACTION / Resolution: 1.86 Å

Chemicals


PDB Unreleased entry

PDB-1cac: Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Protein Degrader

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