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TitleHigh-resolution characterization of ex vivo AAT polymers by solution-state NMR spectroscopy.
Journal, issue, pagesSci Adv, Vol. 11, Page eadu7064-eadu7064, Year 2025
Publish dateAug 13, 2024 (structure data deposition date)
AuthorsLowen, S.M. / Waudby, C.A. / Jagger, A.M. / Aldobiyan, I. / Laffranchi, M. / Fra, A. / Christodoulou, J. / Irving, J.A. / Lomas, D.A.
External linksSci Adv / PubMed:40333971
MethodsX-ray diffraction
Resolution1.84 Å
Structure data

PDB-9ggp:
Alpha-1-antitrypsin in complex with the Fab fragment of an anti-polymer antibody
Method: X-RAY DIFFRACTION / Resolution: 1.84 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsPROTEIN BINDING / Serpin / Fab fragment / monoclonal antibody / selective binding / epitope

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