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TitleLocking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia.
Journal, issue, pagesMol. Ther., Vol. 33, Page 3624-3643, Year 2025
Publish dateMar 25, 2024 (structure data deposition date)
AuthorsAhmed, S.F. / Anand, J. / Zhang, W. / Buetow, L. / Rishi, L. / Mitchell, L. / Bohlen, J. / Lilla, S. / Sibbet, G.J. / Nixon, C. ...Ahmed, S.F. / Anand, J. / Zhang, W. / Buetow, L. / Rishi, L. / Mitchell, L. / Bohlen, J. / Lilla, S. / Sibbet, G.J. / Nixon, C. / Patel, A. / Majorek, K.A. / Zanivan, S. / Bustamante, J.C. / Sidhu, S.S. / Blyth, K. / Huang, D.T.
External linksMol. Ther. / PubMed:40329529
MethodsX-ray diffraction
Resolution2.02 Å
Structure data

PDB-9erz:
Structure of CBL-TKBD bound to Ubiquitin-fused CBLock peptide
Method: X-RAY DIFFRACTION / Resolution: 2.02 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE / Ubiquitin ligase / CBL / peptide inhibitor

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