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TitleDevelopment of PVTX-405 as a potent and highly selective molecular glue degrader of IKZF2 for cancer immunotherapy.
Journal, issue, pagesNat Commun, Vol. 16, Page 4095-4095, Year 2025
Publish dateSep 19, 2024 (structure data deposition date)
AuthorsChen, Z. / Dhruv, H. / Zhang, X. / Rej, R.K. / Bai, L. / McEachern, D. / Kirchhoff, P. / Nagilla, R. / Jolivette, L.J. / Rice, C.T. ...Chen, Z. / Dhruv, H. / Zhang, X. / Rej, R.K. / Bai, L. / McEachern, D. / Kirchhoff, P. / Nagilla, R. / Jolivette, L.J. / Rice, C.T. / Orth, P. / Strickland, C.O. / Priestley, E.S. / Mohammad, H.P. / Wang, M. / Wen, B. / Sun, D. / Sui, Z. / Wang, S.
External linksNat Commun / PubMed:40312344
MethodsX-ray diffraction
Resolution1.69 Å
Structure data

PDB-9dom:
PVTX-405: A Potent, Highly Selective, and Orally Efficacious Molecular Glue Degrader of IKZF2 for Cancer Immunotherapy
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

Chemicals

PDB-1a8n:
SOLUTION STRUCTURE OF A NA+ CATION STABILIZED DNA QUADRUPLEX CONTAINING G.G.G.G AND G.C.G.C TETRADS FORMED BY G-G-G-C REPEATS OBSERVED IN AAV AND HUMAN CHROMOSOME 19, NMR, 8 STRUCTURES

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / Molecular Glue Protein Degrader

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