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Structure paper

TitleMolecular basis of beta 2 integrin activation by talin unveils subunit-specific mechanisms of integrin signaling.
Journal, issue, pagesCell Rep, Vol. 44, Page 115607-115607, Year 2025
Publish dateMay 31, 2023 (structure data deposition date)
AuthorsGao, T. / Maskalenko, N.A. / Kabir, S. / Campbell, K.S. / Wu, J.
External linksCell Rep / PubMed:40310722
MethodsX-ray diffraction
Resolution1.74 - 2.77 Å
Structure data

PDB-8t0d:
Crystal structure of integrin beta-2 tail bound to the FERM-folded talin head domain with E269A/Y270A/K306Q triple mutation
Method: X-RAY DIFFRACTION / Resolution: 2.77 Å

PDB-9c1t:
Crystal structure of integrin beta-3 tail bound to the FERM-folded talin head domain with a D397R mutation
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-9dz5:
Crystal structure of integrin beta-2 tail bound to the FERM-folded talin head domain with a D397R mutation
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsCELL ADHESION / Talin / integrin / Beta-2 / FERM / beta3 / complex

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