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Structure paper

TitleCrystal structures of Kif2A complexed with WDR5 reveal the structural plasticity of WIN-S7 sites.
Journal, issue, pagesActa Biochim. Biophys. Sin., Vol. 57, Page 1999-2010, Year 2025
Publish dateAug 6, 2024 (structure data deposition date)
AuthorsYang, Y. / Zhang, S. / Wu, Z. / Li, W. / Sun, X. / Xuan, Y. / Hang, T. / Xu, L. / Chen, X.
External linksActa Biochim. Biophys. Sin. / PubMed:40302551
MethodsX-ray diffraction
Resolution1.64 - 1.85 Å
Structure data

PDB-9j20:
Structure of WDR5 in complex with KIF2A
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-9jwv:
Structure of WDR5 Y191F in complex with WIN motif containing Kif2A
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-9kd4:
Structure of WDR5 in complex with WIN motif containing Kif2A 114-120
Method: X-RAY DIFFRACTION / Resolution: 1.64 Å

PDB-9kd5:
Structure of WDR5 in complex with WIN motif containing Kif2A S121G
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCYTOSOLIC PROTEIN / WDR5 / WIN motif / KIF2A / NUCLEAR PROTEIN / chromatin

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