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TitlePLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis.
Journal, issue, pagesCancer Discov, Page OF1-OFOF21, Year 2025
Publish dateApr 28, 2025
AuthorsSheue-Fen Tzeng / Yi-Ru Yu / Jaeoh Park / Janusz von Renesse / Huey-Wen Hsiao / Chen-Hsuan Hsu / Josep Garnica / Jintian Chen / Lu-Ting Chiu / Jonas Santol / Tse-Yu Chen / Pei-Han Chung / Lana E Kandalaft / Patrick Starlinger / Rodney Cheng-En Hsieh / Ming-Chin Yu / Pei-Wen Hsiao / Santiago J Carmona / Hung-Kai Chen / Zhen Meng / Yun-Han Lin / Jingying Zhou / Chin-Hsien Tsai / Ping-Chih Ho /
PubMed AbstractDespite the success of cancer immunotherapies, like immune checkpoint inhibitors, many patients still fail to demonstrate significant responses because of metabolic constraints in tumors. PLT012 ...Despite the success of cancer immunotherapies, like immune checkpoint inhibitors, many patients still fail to demonstrate significant responses because of metabolic constraints in tumors. PLT012 rejuvenates antitumor immunity by targeting metabolic pathways to reprogram the immune landscape of liver cancer and liver metastasis, with potential to influence future HCC immunotherapy.
External linksCancer Discov / PubMed:40294022 / PubMed Central
MethodsEM (single particle)
Resolution3.32 Å
Structure data

EMDB-52203: Cryo-EM structure of CD36 protein complex with Fab
Method: EM (single particle) / Resolution: 3.32 Å

Source
  • Cricetulus griseus (Chinese hamster)

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