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TitleStructure-guided engineering of CD112 receptor variants for optimized immunotherapy.
Journal, issue, pagesMol. Ther., Vol. 33, Page 3590-3604, Year 2025
Publish dateOct 31, 2024 (structure data deposition date)
AuthorsSingh, S. / Julia, E. / Kalita, P. / Mason, C. / Ming, Q. / Lee-Sam, A. / Gordon, S. / Buitrago, M.E. / Leung, D.W. / Hwu, P. / Luca, V.C.
External linksMol. Ther. / PubMed:40285356
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-9e6y:
Structure of CD112 (Nectin-2) domain 1 bound to CD112R (PVRIG)
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNOSUPPRESSANT / Checkpoint receptor Immunoglobulin folding

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