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Structure paper

TitleStructural basis for saxitoxin congener binding and neutralization by anuran saxiphilins.
Journal, issue, pagesNat Commun, Vol. 16, Page 3885-3885, Year 2025
Publish dateDec 1, 2023 (structure data deposition date)
AuthorsZakrzewska, S. / Nixon, S.A. / Chen, Z. / Hajare, H.S. / Park, E.R. / Mulcahy, J.V. / Arlinghaus, K.M. / Neu, E. / Konovalov, K. / Provasi, D. ...Zakrzewska, S. / Nixon, S.A. / Chen, Z. / Hajare, H.S. / Park, E.R. / Mulcahy, J.V. / Arlinghaus, K.M. / Neu, E. / Konovalov, K. / Provasi, D. / Leighfield, T.A. / Filizola, M. / Du Bois, J. / Minor Jr., D.L.
External linksNat Commun / PubMed:40274765
MethodsX-ray diffraction
Resolution1.8 - 1.95 Å
Structure data

PDB-8v65:
Nanorana parkeri saxiphilin:dcGTX2 (co-crystal)
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-8v66:
Nanorana parkeri saxiphilin:GTX5 (co-crystal)
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-8v67:
Nanorana parkeri saxiphilin:C1 (co-crystal)
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-8v68:
Nanorana parkeri saxiphilin:dcSTX (co-crystal)
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-8v69:
Nanorana parkeri saxiphilin:GTX2 (co-crystal)
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM


ChemComp, No image

ChemComp-YGU:
Unknown entry

ChemComp-HOH:
WATER


ChemComp, No image

ChemComp-YGZ:
Unknown entry


ChemComp, No image

ChemComp-YH9:
Unknown entry


ChemComp, No image

ChemComp-YGF:
Unknown entry


ChemComp, No image

ChemComp-YGQ:
Unknown entry

Source
  • nanorana parkeri (frog)
KeywordsANTITOXIN / Saxiphilin / Toxin resistance / Saxitoxin

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