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Structure paper

TitleStructure and catalytic mechanism of methylisocitrate lyase, a potential drug target against Coxiella burnetii.
Journal, issue, pagesJ. Biol. Chem., Vol. 301, Page 108517-108517, Year 2025
Publish dateNov 19, 2024 (structure data deposition date)
AuthorsStuart, W.S. / Jenkins, C.H. / Ireland, P.M. / Isupov, M.N. / Norville, I.H. / Harmer, N.J.
External linksJ. Biol. Chem. / PubMed:40250561
MethodsX-ray diffraction
Resolution1.6 - 2.48 Å
Structure data

PDB-9hgk:
Crystal Structure of the Coxiella burnetii 2-methylisocitrate lyase
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-9hgo:
Crystal Structure of the Coxiella burnetii E110Q Mutant 2-methylisocitrate lyase
Method: X-RAY DIFFRACTION / Resolution: 1.82 Å

PDB-9hgq:
Crystal Structure of the Coxiella burnetii 2-methylisocitrate lyase Bound to Substrate 2-MIC
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-9hhs:
Crystal Structure of the Coxiella burnetii R152Q Mutant 2-methylisocitrate lyase
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-9hhy:
Crystal Structure of the Coxiella burnetii 2-methylisocitrate lyase Bound to Inhibitor Isocitric Acid
Method: X-RAY DIFFRACTION / Resolution: 2.33 Å

PDB-9hra:
Crystal Structure of the Coxiella burnetii 2-methylisocitrate lyase Bound to Products Succinic and Pyruvic Acid
Method: X-RAY DIFFRACTION / Resolution: 2.48 Å

Chemicals

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-MIC:
ALPHA-METHYLISOCITRIC ACID

ChemComp-EOH:
ETHANOL

ChemComp-MG:
Unknown entry

ChemComp-CIT:
CITRIC ACID

ChemComp-ICT:
ISOCITRIC ACID

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-SIN:
SUCCINIC ACID

ChemComp-PYR:
PYRUVIC ACID

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

Source
  • coxiella burnetii (bacteria)
KeywordsCYTOSOLIC PROTEIN / PrpB / methylisocitrate lyase / carbon-carbon lyase / EC 4.1.3.30

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