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Structure paper

TitleStructural and antigen-binding surface definition of an anti-CD93 monoclonal antibody for the treatment of degenerative vascular eye diseases.
Journal, issue, pagesInt. J. Biol. Macromol., Vol. 309, Page 143118-143118, Year 2025
Publish dateJan 9, 2025 (structure data deposition date)
AuthorsRaucci, L. / Perrone, C.D. / Barbera, S. / de Boer, L.J. / Tosi, G.M. / Brunetti, J. / Bracci, L. / Pozzi, C. / Galvagni, F. / Orlandini, M.
External linksInt. J. Biol. Macromol. / PubMed:40228767
MethodsX-ray diffraction
Resolution1.6 - 1.81 Å
Structure data

PDB-9hy1:
sc-4E (scFv derived from the mAb 4E1 against CD93) crystallized at pH 7.5 (dimeric state from gel filtration)
Method: X-RAY DIFFRACTION / Resolution: 1.81 Å

PDB-9hy2:
sc-4E (scFv derived from the mAb 4E1 against CD93) crystallized at pH 7.5 (monomeric state from gel filtration)
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-9hy3:
sc-4E (scFv derived from the mAb 4E1 against CD93) crystallized at pH 5.5
Method: X-RAY DIFFRACTION / Resolution: 1.62 Å

PDB-9hy5:
sc-4E (scFv derived from the mAb 4E1 against CD93) crystallized at pH 9.0
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-IMD:
IMIDAZOLE

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / single-chain antibody fragment / scFv / monoclonal antibody 4E1 against CD93 / sc-4E

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