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TitleStructural insights into the assembly and regulation of 2'-O RNA methylation by SARS-CoV-2 nsp16/nsp10.
Journal, issue, pagesStructure, Vol. 33, Page 1027-1039.e4, Year 2025
Publish dateJan 29, 2024 (structure data deposition date)
AuthorsMisra, A. / Rahisuddin, R. / Parihar, M. / Arya, S. / Viswanathan, T. / Jackson, N. / Qi, S. / Chan, S.H. / Harris, R.S. / Martinez-Sobrido, L. / Gupta, Y.K.
External linksStructure / PubMed:40220753
MethodsX-ray diffraction
Resolution2.39 Å
Structure data

PDB-8vuo:
Crystal structure of SARS-CoV-2 nsp16/nsp10 in complex with Cap-1 RNA
Method: X-RAY DIFFRACTION / Resolution: 2.39 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ZN:
Unknown entry

ChemComp-M7G:
7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE

ChemComp-HOH:
WATER

Source
  • severe acute respiratory syndrome coronavirus 2
KeywordsVIRAL PROTEIN / 2'-O methyltransferase / allosteric regulation / RNA methylation

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