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Structure paper

TitleStructural basis of ZP2-targeted female nonhormonal contraception.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 122, Page e2426057122-e2426057122, Year 2025
Publish dateOct 21, 2024 (structure data deposition date)
AuthorsDioguardi, E. / Stsiapanava, A. / Fahrenkamp, E. / Han, L. / de Sanctis, D. / Inzunza, J. / Jovine, L.
External linksProc. Natl. Acad. Sci. USA / PubMed:40215272
MethodsX-ray diffraction
Resolution1.53 - 2.02 Å
Structure data

PDB-9h4r:
Structure of fertilization-blocking monoclonal antibody IE-3 VHVL bound to the ZP-N1 domain of mouse ZP2 (crystal form I)
Method: X-RAY DIFFRACTION / Resolution: 1.53 Å

PDB-9h4s:
Structure of fertilization-blocking monoclonal antibody IE-3 VHVL bound to the ZP-N1 domain of mouse ZP2 (crystal form II)
Method: X-RAY DIFFRACTION / Resolution: 2.02 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • rattus norvegicus (Norway rat)
KeywordsCELL ADHESION / Zona pellucida / ZP2 / ZP-N domain / ZP-N1 domain / ZP module / ZP domain / egg-sperm recognition / gamete interaction / immunocontraception / monoclonal antibody / IE-3 / IE3 / heavy chain variable domain / light chain variable domain

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