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TitleStructural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4.
Journal, issue, pagesProc Natl Acad Sci U S A, Vol. 122, Issue 15, Page e2417148122, Year 2025
Publish dateApr 15, 2025
AuthorsMengting Jiang / Youwei Xu / Xiaodong Luan / Kai Wu / Zhen Li / H Eric Xu / Shuyang Zhang / Yi Jiang / Wanchao Yin /
PubMed AbstractThe G protein-coupled cysteinyl leukotriene receptor CysLT2R plays intricate roles in the physiology and pathogenesis of inflammation-related processes. It has garnered increasing attention as a ...The G protein-coupled cysteinyl leukotriene receptor CysLT2R plays intricate roles in the physiology and pathogenesis of inflammation-related processes. It has garnered increasing attention as a potential therapeutic target for atopic asthma, brain injury, central nervous system disorders, and various types of cancer. In this study, we present the cryo-electron microscopy structure of the cysteinyl leukotriene D4 (LTD4)-bound human CysLT2R in complex with a Gα protein, adopting an active conformation at a resolution of 3.15 Å. The structure elucidates a spacious polar pocket designed to accommodate the two branched negative ends of LTD4 and reveals a lateral ligand access route into the orthosteric pocket located on transmembrane domain helix (TM) 4 and 5. Furthermore, our findings highlight the crucial role of transmembrane domain helix 3 in sensing agonist moieties, representing the pivotal mechanism of receptor activation for both CysLT1R and CysLT2R. Collectively, the insights derived from our structural investigation establish a foundation for comprehending CysLT2R activation by its endogenous ligand LTD4, offering a rational basis for the design of drugs targeting CysLT2R.
External linksProc Natl Acad Sci U S A / PubMed:40193607 / PubMed Central
MethodsEM (single particle)
Resolution3.15 Å
Structure data

60980

9ixx

EMDB-60980, PDB-9ixx:
Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4
Method: EM (single particle) / Resolution: 3.15 Å

Chemicals

ChemComp-LTD:
(5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-azanyl-3-(2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid

Source
  • homo sapiens (human)
  • rattus norvegicus (Norway rat)
KeywordsMEMBRANE PROTEIN/IMMUNE SYSTEM / GPCR / CysLT2R / LTD4 / MEMBRANE PROTEIN-IMMUNE SYSTEM complex

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