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TitleTherapeutic potential of allosteric HECT E3 ligase inhibition.
Journal, issue, pagesCell, Vol. 188, Page 2603-, Year 2025
Publish dateJun 21, 2024 (structure data deposition date)
AuthorsRothman, A.M.K. / Florentin, A. / Zink, F. / Quigley, C. / Bonneau, O. / Hemmig, R. / Hachey, A. / Rejtar, T. / Thaker, M. / Jain, R. ...Rothman, A.M.K. / Florentin, A. / Zink, F. / Quigley, C. / Bonneau, O. / Hemmig, R. / Hachey, A. / Rejtar, T. / Thaker, M. / Jain, R. / Huang, S.M. / Sutton, D. / Roger, J. / Zhang, J.H. / Weiler, S. / Cotesta, S. / Ottl, J. / Srivastava, S. / Kordonsky, A. / Avishid, R. / Yariv, E. / Rathi, R. / Khvalevsky, O. / Troxler, T. / Binmahfooz, S.K. / Kleifeld, O. / Morrell, N.W. / Humbert, M. / Thomas, M.J. / Jarai, G. / Beckwith, R.E.J. / Cobb, J.S. / Smith, N. / Ostermann, N. / Tallarico, J. / Shaw, D. / Guth-Gundel, S. / Prag, G. / Rowlands, D.J.
External linksCell / PubMed:40179885
MethodsX-ray diffraction
Resolution2.05 - 2.75 Å
Structure data

PDB-9fsh:
Crystal structure of the HECT domain of Smurf 2 in complex with inhibitor 8
Method: X-RAY DIFFRACTION / Resolution: 2.08 Å

PDB-9fsj:
Crystal structure of the HECT domain of Smurf 1 in complex with inhibitor 8
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

PDB-9fsk:
Crystal structure of the HECT domain of Smurf1
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals


ChemComp, No image

ChemComp-TJQ:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE / E3 ubiquitin-protein ligase SMURF2 / HECT domain / inhibitor / allosteric inhibition / BMP signaling / pulmonary vascular remodeling / E3 ubiquitin-protein ligase SMURF1 / HECT-type E3 ligase

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