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Title3,5-Dihydroxybenzoic Acid as a Potent Inhibitor of Tyrosine Phenol-Lyase Decreases Fecal Phenol Levels in Mice.
Journal, issue, pagesJ. Med. Chem., Vol. 68, Page 8786-8795, Year 2025
Publish dateAug 8, 2024 (structure data deposition date)
AuthorsKobayashi, T. / Oishi, S. / Hara, K. / Matsui, M. / Mena, P. / Hashimoto, H. / Watanabe, K. / Miyoshi, N.
External linksJ. Med. Chem. / PubMed:40173106
MethodsX-ray diffraction
Resolution1.83 Å
Structure data

PDB-9j3u:
Crystal structure of tyrosine phenol-lyase in complex with 3,5-dihydroxybenzoic acid
Method: X-RAY DIFFRACTION / Resolution: 1.83 Å

Chemicals

ChemComp-34D:
3,5-DIHYDROXYBENZOATE

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

Source
  • morganella morganii subsp. morganii (bacteria)
KeywordsLYASE / plp-dependent enzyme / pyridoxal-5'-phosphate / 3 / 5-dihydroxybenzoic acid

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