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TitleUridine Embedded within DNA is Repaired by Uracil DNA Glycosylase via a Mechanism Distinct from That of Ribonuclease H2.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 147, Page 11574-11583, Year 2025
Publish dateJan 21, 2025 (structure data deposition date)
AuthorsFan, C. / Zhan, X. / Guo, F. / Li, Q. / Lu, K. / Shan, X. / Zhou, Y. / Ren, M. / Greenberg, M.M. / Liu, Y. / Zhou, C.
External linksJ. Am. Chem. Soc. / PubMed:40130361
MethodsX-ray diffraction
Resolution1.74 - 1.76 Å
Structure data

PDB-9lnp:
the hUNG bound to DNA product embedding uridine ribonucleotide
Method: X-RAY DIFFRACTION / Resolution: 1.76 Å

PDB-9lnq:
The hUNG bound to DNA product embedding 4primer-OCH3-dU
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-NA:
Unknown entry

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN/DNA / uracil DNA glycosylase uridine ribonucleotide DNA damage base excision repair / DNA BINDING PROTEIN-DNA complex

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