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Structure paper

TitleDesign of orthogonal constant domain interfaces to aid proper heavy/light chain pairing of bispecific antibodies.
Journal, issue, pagesMabs, Vol. 17, Page 2479531-2479531, Year 2025
Publish dateDec 10, 2024 (structure data deposition date)
AuthorsBarlow, K.A. / Battles, M.B. / Brown, M.E. / Canfield, K. / Lu, X. / Lynaugh, H. / Morrill, M. / Rappazzo, C.G. / Reyes, S.P. / Sandberg, C. ...Barlow, K.A. / Battles, M.B. / Brown, M.E. / Canfield, K. / Lu, X. / Lynaugh, H. / Morrill, M. / Rappazzo, C.G. / Reyes, S.P. / Sandberg, C. / Sharkey, B. / Strong, C. / Zhao, J. / Sivasubramanian, A.
External linksMabs / PubMed:40126074
MethodsX-ray diffraction
Resolution2.22 - 2.35 Å
Structure data

PDB-9mfn:
Crystal Structure of ADI-64596 (human Fab, with substituted IgG1-CH1 (HC-L145Q, K147E, and S181E) and substituted kappa constant domain (LC-T129R, T178R, and T180Q))
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-9mi7:
Crystal Structure of ADI-64597 ((human Fab, with substituted IgG1-CH1 (HC-L128R and K147R) and substituted kappa constant domain (LC-Q124E, V133Q, and T178R))
Method: X-RAY DIFFRACTION / Resolution: 2.22 Å

Chemicals

ChemComp-BR:
BROMIDE ION

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / antibody

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