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Title23ME-01473, an Fc Effector-Enhanced Anti-ULBP6/2/5 Antibody, Restores NK Cell-Mediated Antitumor Immunity through NKG2D and Fc gamma RIIIa Activation.
Journal, issue, pagesCancer Res Commun, Vol. 5, Page 476-495, Year 2025
Publish dateFeb 2, 2024 (structure data deposition date)
AuthorsBenjamin, J.S. / Jarret, A. / Bharill, S. / Fontanillas, P. / Yadav, S. / Sen, D. / Ayupova, D. / Kellar, D. / Tilk, S. / Hom, C. ...Benjamin, J.S. / Jarret, A. / Bharill, S. / Fontanillas, P. / Yadav, S. / Sen, D. / Ayupova, D. / Kellar, D. / Tilk, S. / Hom, C. / Bahrami Dizicheh, Z. / Chen, I.L. / Diep, A.N. / Shi, S. / Ivic, N. / Bonnans, C. / Owyang, A. / Sood, P. / Fuh, G. / Schmidt, M. / Gerrick, K.Y. / Koenig, P. / Poggio, M.
External linksCancer Res Commun / PubMed:40116579
MethodsX-ray diffraction
Resolution2.307 Å
Structure data

PDB-8rwb:
Crystal structure of ULBP6 in complex with a blocking antibody
Method: X-RAY DIFFRACTION / Resolution: 2.307 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / FAB

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