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| Title | CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety. |
|---|---|
| Journal, issue, pages | Cancer Cell, Vol. 43, Page 464-481.e14, Year 2025 |
| Publish date | Jul 24, 2024 (structure data deposition date) |
 Authors | Palmer, C.L. / Boras, B. / Pascual, B. / Li, N. / Li, D. / Garza, S. / Huser, N. / Yuan, J.T. / Cianfrogna, J.A. / Sung, T. ...Palmer, C.L. / Boras, B. / Pascual, B. / Li, N. / Li, D. / Garza, S. / Huser, N. / Yuan, J.T. / Cianfrogna, J.A. / Sung, T. / McMillan, E. / Wei, N. / Carmody, J. / Kang, A.N. / Darensburg, S. / Dodd, T. / Oakley, J.V. / Solowiej, J. / Nguyen, L. / Orr, S.T.M. / Chen, P. / Johnson, E. / Yu, X. / Diehl, W.C. / Gallego, G.M. / Jalaie, M. / Ferre, R.A. / Cho-Schultz, S. / Shen, H. / Deal, J.G. / Zhang, Q. / Baffi, T.R. / Xu, M. / Roh, W. / Lapira-Miller, J. / Goudeau, J. / Yu, Y. / Gupta, R. / Kim, K. / Dann, S.G. / Kan, Z. / Kath, J.C. / Nair, S.K. / Miller, N. / Murray, B.W. / Nager, A.R. / Quinlan, C. / Petroski, M.D. / Zhang, C. / Sacaan, A. / VanArsdale, T. / Anders, L. |
 External links | Cancer Cell / PubMed:40068598 |
| Methods | X-ray diffraction |
| Resolution | 2 - 2.253 Å |
| Structure data |  PDB-9csk:  PDB-9d8u: |
| Chemicals |  PDB-1az4:  ChemComp-HOH: |
| Source |
|
 Keywords | Transferase/Inhibitor/Cell Cycle / Kinase / Inhibitor / Cancer / Transferase-Inhibitor-Cell Cycle complex / TRANSFERASE |
homo sapiens (human)