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TitleAllosteric inhibition of cytosolic NADP + -dependent isocitrate dehydrogenase by oxaloacetate.
Journal, issue, pagesJ. Struct. Biol., Vol. 217, Page 108183-108183, Year 2025
Publish dateAug 23, 2023 (structure data deposition date)
AuthorsKim, D.K. / Cho, H.Y. / Cho, H.J. / Kang, B.S.
External linksJ. Struct. Biol. / PubMed:40064325
MethodsX-ray diffraction
Resolution1.7 - 1.77 Å
Structure data

PDB-8kib:
NADP+-dependent cytosolic isocitrate dehydrogenase complexed with oxaloacetate
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-8w49:
mouse isocitrate dehydrogenase with isocitrate and magnesium
Method: X-RAY DIFFRACTION / Resolution: 1.77 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-OAA:
OXALOACETATE ION

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-ICT:
ISOCITRIC ACID

Source
  • mus musculus (house mouse)
KeywordsOXIDOREDUCTASE / isocitrate dehydrogenase allosteric inhibition inhibitor complex / isocitrate dehydrogenase enzyme-substrate complex oxidoreductase homodimer

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