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TitleHighly Specific Miniaturized Fluorescent Monoacylglycerol Lipase Probes Enable Translational Research.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 147, Page 10188-10202, Year 2025
Publish dateFeb 1, 2024 (structure data deposition date)
AuthorsHentsch, A. / Guberman, M. / Radetzki, S. / Kaushik, S. / Huizenga, M. / He, Y. / Contzen, J. / Kuhn, B. / Benz, J. / Schippers, M. ...Hentsch, A. / Guberman, M. / Radetzki, S. / Kaushik, S. / Huizenga, M. / He, Y. / Contzen, J. / Kuhn, B. / Benz, J. / Schippers, M. / Paul, J. / Leibrock, L. / Collin, L. / Wittwer, M. / Topp, A. / O'Hara, F. / Heer, D. / Hochstrasser, R. / Blaising, J. / von Kries, J.P. / Mu, L. / van der Stelt, M. / Mergenthaler, P. / Lipstein, N. / Grether, U. / Nazare, M.
External linksJ. Am. Chem. Soc. / PubMed:40063733
MethodsX-ray diffraction
Resolution1.43 Å
Structure data

PDB-8rvf:
CRYSTAL STRUCTURE OF HUMAN MONOGLYCERIDE LIPASE IN COMPLEX WITH COMPOUND 5
Method: X-RAY DIFFRACTION / Resolution: 1.43 Å

Chemicals

PDB-1h35:
Structures of Human Oxidosqualene Cyclase Inhibitors Bound to an Homologous Enzyme

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / ALPHA/BETA HYDROLASE / SERINE ESTERASE;

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