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TitleDiscovery of a fluorinated macrobicyclic antibiotic through chemical synthesis.
Journal, issue, pagesNat. Chem., Vol. 17, Page 582-589, Year 2025
Publish dateAug 7, 2024 (structure data deposition date)
AuthorsTresco, B.I.C. / Wu, K.J.Y. / Ramkissoon, A. / Aleksandrova, E.V. / Purdy, M. / See, D.N.Y. / Liu, R.Y. / Polikanov, Y.S. / Myers, A.G.
External linksNat. Chem. / PubMed:40055575
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-9d0j:
Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with BT-33, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-MG:
Unknown entry

PDB-1a1l:
ZIF268 ZINC FINGER-DNA COMPLEX (GCAC SITE)

ChemComp-ZN:
Unknown entry

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
  • thermus thermophilus hb8 (bacteria)
  • escherichia phage t4 (virus)
KeywordsRIBOSOME / BT-33; cresomycin; lincosamides; structure-based drug design; antibiotic; 70S ribosome; X-ray structure; inhibition of translation; peptidyl transferase center; nascent peptide exit tunnel

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