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TitleTrivalent siRNA-Conjugates with Guanosine as ASGPR-Binder Show Potent Knock-Down In Vivo.
Journal, issue, pagesJ. Med. Chem., Vol. 68, Page 6193-6209, Year 2025
Publish dateJul 19, 2024 (structure data deposition date)
AuthorsHofmeister, A. / Jahn-Hofmann, K. / Brunner, B. / Helms, M. / Metz-Weidmann, C. / Poeverlein, C. / Zech, G. / Li, Z. / Hessler, G. / Schreuder, H. ...Hofmeister, A. / Jahn-Hofmann, K. / Brunner, B. / Helms, M. / Metz-Weidmann, C. / Poeverlein, C. / Zech, G. / Li, Z. / Hessler, G. / Schreuder, H. / Elshorst, B. / Krack, A. / Kurz, M. / Heubel, C. / Scheidler, S.
External linksJ. Med. Chem. / PubMed:40052708
MethodsX-ray diffraction
Resolution1.199 - 1.588 Å
Structure data

PDB-9g76:
Crystal structure of ASGPR with bound GalNAc
Method: X-RAY DIFFRACTION / Resolution: 1.199 Å

PDB-9g7d:
Crystal structure of ASGPR with bound IMP
Method: X-RAY DIFFRACTION / Resolution: 1.588 Å

PDB-9g7e:
Crystal structure of ASGPR with bound guanosine
Method: X-RAY DIFFRACTION / Resolution: 1.398 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-A2G:
2-acetamido-2-deoxy-alpha-D-galactopyranose

ChemComp-NGA:
2-acetamido-2-deoxy-beta-D-galactopyranose

ChemComp-HOH:
WATER

ChemComp-IMP:
INOSINIC ACID

ChemComp-GMP:
GUANOSINE

Source
  • homo sapiens (human)
KeywordsSUGAR BINDING PROTEIN / ASIALO GLYCOPROTEIN RECEPTOR / SUGAR BINDING / NATURAL LIGAND COMPLEX / siRNA targeting / LIGAND COMPLEX

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