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Structure paper

TitleMDC1 mediates Pellino recruitment to sites of DNA double-strand breaks.
Journal, issue, pagesLife Sci Alliance, Vol. 8, Year 2025
Publish dateFeb 17, 2025 (structure data deposition date)
AuthorsTorres Esteban, M. / Stewart, M.J. / Bragginton, E. / Meroni, A. / Pellizzari, A. / Jeanrenaud, A. / Smerdon, S.J. / Stucki, M.
External linksLife Sci Alliance / PubMed:40049731
MethodsX-ray diffraction
Resolution2.55 Å
Structure data

PDB-9if9:
Crystal structure of the Pellino 1 FHA domain in complex with a MDC1-TQxF phosphopeptide.
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPEPTIDE BINDING PROTEIN / FHA / phosphopeptide binding domain / RING / E3 ligase / DNA damage / DNA repair

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