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Structure paper

TitleStructure-function relationship of ASH1L and histone H3K36 and H3K4 methylation.
Journal, issue, pagesNat Commun, Vol. 16, Page 2235-2235, Year 2025
Publish dateJan 11, 2024 (structure data deposition date)
AuthorsVann, K.R. / Sharma, R. / Hsu, C.C. / Devoucoux, M. / Tencer, A.H. / Zeng, L. / Lin, K. / Zhu, L. / Li, Q. / Lachance, C. ...Vann, K.R. / Sharma, R. / Hsu, C.C. / Devoucoux, M. / Tencer, A.H. / Zeng, L. / Lin, K. / Zhu, L. / Li, Q. / Lachance, C. / Ospina, R.R. / Tong, Q. / Cheung, K.L. / Yang, S. / Biswas, S. / Xuan, H. / Gatchalian, J. / Alamillo, L. / Wang, J. / Jang, S.M. / Klein, B.J. / Lu, Y. / Ernst, P. / Strahl, B.D. / Rothbart, S.B. / Walsh, M.J. / Cleary, M.L. / Cote, J. / Shi, X. / Zhou, M.M. / Kutateladze, T.G.
External linksNat Commun / PubMed:40044670
MethodsX-ray diffraction
Resolution1.34 - 2.403 Å
Structure data

PDB-8vld:
Crystal structure of Ash1L PHD finger in complex with histone H3K4me2
Method: X-RAY DIFFRACTION / Resolution: 1.92 Å

PDB-8vlf:
Crystal structure of Ash1L PHD finger in complex with histone H3K4me3
Method: X-RAY DIFFRACTION / Resolution: 1.34 Å

PDB-8vlh:
Crystal structure of Ash1L PHD-BAH domains
Method: X-RAY DIFFRACTION / Resolution: 2.403 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-SR:
STRONTIUM ION

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Ash1L / H3K4me2 / zinc finger / transcriptional regulation / methyltransferase / PHD / BAH

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