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Structure paper

TitleAllosteric inhibition of the IZUMO1-JUNO fertilization complex by the naturally occurring antisperm antibody OBF13.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 122, Page e2425952122-e2425952122, Year 2025
Publish dateJan 22, 2025 (structure data deposition date)
AuthorsLu, Y. / Ikawa, M. / Tang, S.
External linksProc. Natl. Acad. Sci. USA / PubMed:40042902
MethodsX-ray diffraction
Resolution1.843 - 3.177 Å
Structure data

PDB-9myl:
Fertilization IZUMO1 Protein Ectodomain in Complex with Anti-sperm Antibody OBF13
Method: X-RAY DIFFRACTION / Resolution: 3.177 Å

PDB-9mym:
Fertilization IZUMO1 Protein Ectodomain
Method: X-RAY DIFFRACTION / Resolution: 1.843 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-PRO:
PROLINE

ChemComp-CL:
Unknown entry

ChemComp-FUC:
alpha-L-fucopyranose

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsCELL ADHESION / Fertilization / Anti-sperm antibody / IZUMO1 / Infertility / Contraception

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