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TitleDiscovery of Potent and Selective MNK Kinase Inhibitors for the Treatment of Leukemia.
Journal, issue, pagesJ. Med. Chem., Vol. 68, Page 5824-5844, Year 2025
Publish dateDec 17, 2024 (structure data deposition date)
AuthorsVagadia, P.P. / Izquierdo-Ferrer, J. / Mazewski, C. / Blyth, G. / Beauchamp, E.M. / Clutter, M.R. / Stern, C.L. / Mishra, R.K. / Nahotko, D. / Small, S. ...Vagadia, P.P. / Izquierdo-Ferrer, J. / Mazewski, C. / Blyth, G. / Beauchamp, E.M. / Clutter, M.R. / Stern, C.L. / Mishra, R.K. / Nahotko, D. / Small, S. / Eckerdt, F. / Platanias, L.C. / Schiltz, G.E.
External linksJ. Med. Chem. / PubMed:40033556
MethodsX-ray diffraction
Resolution3.161 Å
Structure data

PDB-9hrc:
Structure of MNK2 in complex with inhibitor NUCC-0201049
Method: X-RAY DIFFRACTION / Resolution: 3.161 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-GOL:
GLYCEROL

PDB-1iwo:
Crystal structure of the SR Ca2+-ATPase in the absence of Ca2+

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE / MNK2 / inhibitor / NUCC-020149

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