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TitleStructure-based Design of Chimeric Influenza Hemagglutinins to Elicit Cross-group Immunity.
Journal, issue, pagesBiorxiv, Year 2025
Publish dateDec 8, 2024 (structure data deposition date)
AuthorsCastro, K.M. / Ayardulabi, R. / Wehrle, S. / Cui, H. / Georgeon, S. / Schmidt, J. / Xiao, S. / Seraj, N. / Harshbarger, W. / Mallett, C.P. ...Castro, K.M. / Ayardulabi, R. / Wehrle, S. / Cui, H. / Georgeon, S. / Schmidt, J. / Xiao, S. / Seraj, N. / Harshbarger, W. / Mallett, C.P. / Vassilev, V. / Saelens, X. / Correia, B.E.
External linksBiorxiv / PubMed:40027756
MethodsX-ray diffraction
Resolution2 - 2.06 Å
Structure data

PDB-9mer:
Structure of H1H5:FluA20 Chimeric Influenza HA Complex
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-9mev:
Structure of H1H3:FluA20 Chimeric Antigen Complex
Method: X-RAY DIFFRACTION / Resolution: 2.06 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

Source
  • influenza a virus
  • homo sapiens (human)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / Influenza / Hemagglutinins / HA / Chimera H1 / H5 / VIRAL PROTEIN-IMMUNE SYSTEM complex / Hemagglutinin / Antigen / Antibody

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