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TitleDevelopment of 3-arylaminothiophenic-2-carboxylic acid derivatives as new FTO inhibitors showing potent antileukemia activities.
Journal, issue, pagesEur. J. Med. Chem., Vol. 289, Page 117444-117444, Year 2025
Publish dateNov 19, 2024 (structure data deposition date)
AuthorsZhang, D. / Liu, L. / Li, M. / Hu, X. / Zhang, X. / Xia, W. / Wang, Z. / Song, X. / Huang, Y. / Dong, Z. / Yang, C.G.
External linksEur. J. Med. Chem. / PubMed:40022879
MethodsX-ray diffraction
Resolution2.63 Å
Structure data

PDB-9kni:
Structural complex of FTO bound with 12j
Method: X-RAY DIFFRACTION / Resolution: 2.63 Å

Chemicals

ChemComp-AKG:
2-OXOGLUTARIC ACID

PDB-1ef5:
SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF RGL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / m6A eraser / FTO Inhibitor / Complex

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